In the past decade, the idea that single populations of neurons support cognition and
behavior has gradually given way to the realization that connectivity matters and that …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer
the possibility to non-invasively probe whole-brain network dynamics and to investigate the …

Background: Strong genetic and epidemiological evidence points to a crucial role of the
immune system in the development of Alzheimer disease (AD). CD3+ T lymphocytes have …

fMRI studies in mice typically require the use of anesthetics. Yet, it is known that anesthesia
alters responses to stimuli or functional networks at rest. In this work, we have used Dual …

Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the
focus of numerous studies. Transgenic mouse models have been instrumental to study …

Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made
great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite …

Synchronous low-frequency oscillation in the resting human brain has been found to form
networks of functionally associated areas and hence has been widely used to map the …

In recent years precision fMRI has emerged in human brain research, demonstrating
characterization of individual differences in brain organization. However, mechanistic …

Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are
thought to alter various aspects of tissue microstructure, such as extracellular free water …