Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Advances in peptide-based drug delivery systems

S Guo, J Wang, Q Wang, J Wang, S Qin, W Li - Heliyon, 2024 - cell.com
Drug-delivery systems (DDSs) are designed to deliver drugs to their specific targets to
minimize their toxic effects and improve their susceptibility to clearance during targeted …

Targeting Mitochondrial Guanine Quadruplexes for Photoactivatable Chemotherapy in Hypoxic Environments

L Holden, RC Curley, G Avella, C Long… - Angewandte …, 2024 - Wiley Online Library
A first example of a mitochondrial G‐quadruplex (mitoG4s) targeted Ru (II) photooxidant
complex is reported. The complex, Ru‐TAP‐PDC3 induces photodamage toward guanine …

A dinuclear osmium (II) complex near-infrared nanoscopy probe for nuclear DNA

F Dröge, FF Noakes, SA Archer… - Journal of the …, 2021 - ACS Publications
With the aim of developing photostable near-infrared cell imaging probes, a convenient
route to the synthesis of heteroleptic OsII complexes containing the Os (TAP) 2 fragment is …

Selective, disruptive luminescent Ru (II) polypyridyl probes of G-quadruplex

L Holden, KS Gkika, CS Burke, C Long… - Inorganic …, 2023 - ACS Publications
Sensors capable of transducing G-quadruplex DNA binding are important both in solution
and for imaging and interrogation in cellulo. Ru (II)-based light switches incorporating …

Phototoxicity of Tridentate Ru (II) Polypyridyl Complex with Expanded Bite Angles toward Mammalian Cells and Multicellular Tumor Spheroids

RC Curley, CS Burke, KS Gkika, S Noorani… - Inorganic …, 2023 - ACS Publications
Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N–Ru–N bite
angles have been shown to promote ligand field splitting and reduce singlet–triplet state …

Metal peptide conjugates in cell and tissue imaging and biosensing

KS Gkika, D Cullinane, TE Keyes - Metal Ligand Chromophores for …, 2022 - Springer
Metal complex luminophores have seen dramatic expansion in application as imaging
probes over the past decade. This has been enabled by growing understanding of methods …

Recent development of photofunctional transition metal− peptide conjugates for bioimaging and therapeutic applications

LCC Lee, L Huang, PKK Leung… - European Journal of …, 2022 - Wiley Online Library
Peptides are attractive for diagnostic and therapeutic applications due to their small
molecular size, ease of synthesis and chemical modifications, high target affinity and …

On-Resin Conjugation of the Ruthenium Anticancer Agent Plecstatin-1 to Peptide Vectors

S Kumar, M Riisom, SMF Jamieson… - Inorganic …, 2023 - ACS Publications
Ruthenium piano-stool complexes have been explored for their anticancer activity and some
promising compounds have been reported. Herein, we conjugated a derivative of plecstatin …

Luminescent Metal Complexes for Bioassays in Near-infrared (NIR) Region

GQ Jin, LJ Guo, J Zhang, S Gao, JL Zhang - Metal Ligand Chromophores …, 2022 - Springer
Abstract Near-infrared (NIR, 700–1700 nm) luminescent imaging is an emerging bioimaging
technology with low photon scattering, minimal autofluorescence, deep tissue penetration …