Autophagy in kidney homeostasis and disease

C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

[HTML][HTML] Hallmarks of aging: an autophagic perspective

MC Barbosa, RA Grosso, CM Fader - Frontiers in endocrinology, 2019 - frontiersin.org
Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

N Wu, W Zheng, Y Zhou, Y Tian, M Tang, X Feng… - Ageing Research …, 2024 - Elsevier
Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …

Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

S Gupta, PK Panda, RF Hashimoto, SK Samal… - Scientific Reports, 2022 - nature.com
Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with
DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been …

[HTML][HTML] Autophagy modulation and cancer combination therapy: a smart approach in cancer therapy

A Salimi-Jeda, S Ghabeshi, EO Jazaeri… - Cancer Treatment and …, 2022 - Elsevier
The autophagy pathway is the process whereby cells keep cellular homeostasis and
respond to stress via recycling their damaged cellular proteins, organelles, and other …

[HTML][HTML] Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases

C Miceli, M Leri, M Stefani, M Bucciantini - Ageing Research Reviews, 2023 - Elsevier
Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the
production of the energy load needed at critical times during development and in response …

Autophagy: the multi‐purpose bridge in viral infections and host cells

A Abdoli, M Alirezaei, P Mehrbod… - Reviews in medical …, 2018 - Wiley Online Library
Autophagy signaling pathway is involved in cellular homeostasis, developmental processes,
cellular stress responses, and immune pathways. The aim of this review is to summarize the …

Establishing a deeper understanding of the osteogenic differentiation of monolayer cultured human pluripotent stem cells using novel and detailed analyses

P Zhou, JM Shi, JE Song, Y Han, HJ Li… - Stem cell research & …, 2021 - Springer
Background Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is
a popular topic in bone tissue engineering. Although many improvements have been …

Autophagy and aging: Roles in skeletal muscle, eye, brain and hepatic tissue

P Li, Y Ma, C Yu, S Wu, K Wang, H Yi… - Frontiers in Cell and …, 2021 - frontiersin.org
Autophagy is an evolutionary conserved degradative process contributing to cytoplasm
quality control, metabolic recycling and cell defense. Aging is a universal phenomenon …

[HTML][HTML] Relating aging and autophagy: a new perspective towards the welfare of human health

SG Chowdhury, R Ray, P Karmakar - EXCLI journal, 2023 - ncbi.nlm.nih.gov
The most common factor that contributes to aging is the loss of proteostasis, resulting in an
excess amount of non-functional/damaged proteins. These proteins lead to various age …