Butyrate, a main product of gut microbial fermentation, has been recognized as an important
mediator of gut microbiota regulation in whole body energy homeostasis. However, the …

Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

Abstract Type 1 diabetes (T1D) also known as juvenile diabetes is a chronic autoimmune
disorder that precipitates in genetically susceptible individuals by environmental factors …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Hydroxamic acids were designed, synthesized, and evaluated for their ability to selectively
inhibit human histone deacetylase 6 (HDAC6). Several inhibitors, including compound 14 …