Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

The blood-brain barrier (BBB) remains one of the greatest challenges for the discovery and
development of treatments for CNS disorders, which to this day remains one of the riskiest …

New experimental methodologies were applied to measure the unbound brain-to-plasma
concentration ratio (K p, uu, brain) and the unbound CSF-to-plasma concentration ratio (K p …

The first-generation quinolones have their greatest potency against Gram-negative bacteria,
but newly developed molecules have exhibited increased potency against Gram-positive …

As for all other drugs, antibiotics must reach their pharmacodynamic target in order to exert
their effect, but because infection may occur in various tissues the distribution of antibiotics …

The blood-brain barrier (BBB), composed of microvascular tight junctions and glial cell
sheathing, selectively controls drug permeation into the central nervous system (CNS) by …

Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical
properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB) …

The need to discover and develop safe and effective new medicines is greatest for disorders
of the CNS. A core requirement for an effective neurotherapeutic agent is an ability to cross …

Microdialysis has been developed during the last 25 years by several authors primarily to
study brain function and changes in levels of endogenous compounds such as …

Background: Microdialysis studies of antibacterial tissue distribution in critically ill patients
have sometimes led to results that were spectacular but inconsistent with basic …