On the molecular nature of large-pore channels
J Syrjanen, K Michalski, T Kawate… - Journal of molecular …, 2021 - Elsevier
Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
Ion channelopathies of the immune system
Ion channels and transporters move ions across membrane barriers and are essential for a
host of cell functions in many organs. They conduct K+, Na+ and Cl−, which are essential for …
host of cell functions in many organs. They conduct K+, Na+ and Cl−, which are essential for …
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity
C Zhou, X Chen, R Planells-Cases, J Chu, L Wang… - Immunity, 2020 - cell.com
The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling
AR Concepcion, LE Wagner, J Zhu, AY Tao… - Nature …, 2022 - nature.com
The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …
A DNA nanodevice for mapping sodium at single-organelle resolution
Cellular sodium ion (Na+) homeostasis is integral to organism physiology. Our current
understanding of Na+ homeostasis is largely limited to Na+ transport at the plasma …
understanding of Na+ homeostasis is largely limited to Na+ transport at the plasma …
A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
The swelling-activated anion channel VRAC has fascinated and frustrated physiologists
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …
[HTML][HTML] Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer
Y Chen, X Zuo, Q Wei, J Xu, X Liu, S Liu… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Cervical cancer (CC) is one of the most common gynecological malignancies with poor
prognosis for advanced CC patients. LRRC8A is a volume-regulated anion channel protein …
prognosis for advanced CC patients. LRRC8A is a volume-regulated anion channel protein …
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
LRRC8 family proteins on the plasma membrane play a critical role in cellular
osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent …
osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent …
Molecular biology and physiology of volume-regulated anion channel (VRAC)
J Osei-Owusu, J Yang, M del Carmen Vitery… - Current topics in …, 2018 - Elsevier
Abstract The Volume-Regulated Anion Channel (VRAC) is activated by cell swelling and
plays a key role in cell volume regulation. VRAC is ubiquitously expressed in vertebrate …
plays a key role in cell volume regulation. VRAC is ubiquitously expressed in vertebrate …
Cell volume-activated and volume-correlated anion channels in mammalian cells: their biophysical, molecular, and pharmacological properties
Y Okada, T Okada, K Sato-Numata, MR Islam… - Pharmacological …, 2019 - Elsevier
There are a number of mammalian anion channel types associated with cell volume
changes. These channel types are classified into two groups: volume-activated anion …
changes. These channel types are classified into two groups: volume-activated anion …