Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

The TRIM proteins in cancer: from expression to emerging regulatory mechanisms

A Mohammadi, MS Pour Abbasi, S Khorrami… - Clinical and …, 2022 - Springer
New clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of
tumor suppressors or oncogene products is probably engaged in the etiology of leukemia …

Identification of potential key genes in prostate cancer with gene expression, pivotal pathways and regulatory networks analysis using integrated bioinformatics …

MM Khan, MT Mohsen, MZ Malik, SA Bagabir… - Genes, 2022 - mdpi.com
Prostate cancer (PCa) is the most prevalent cancer (20%) in males and is accountable for a
fifth (6.8%) cancer-related deaths in males globally. Smoking, obesity, race/ethnicity, diet …

[HTML][HTML] HSP90AA1 promotes lymphatic metastasis of hypopharyngeal squamous cell carcinoma by regulating epithelial-mesenchymal transition

F Tang, Y Li, M Pan, Z Wang, T Lu, C Liu… - Oncology …, 2023 - ncbi.nlm.nih.gov
Background Lymphatic metastasis (LM) emerges as an independent prognostic marker for
hypopharyngeal squamous cell carcinoma (HSPSCC), chiefly contributing to treatment …

CDK1 and HSP90AA1 appear as the novel regulatory genes in non-small cell lung cancer: a bioinformatics approach

N Bhattacharyya, S Gupta, S Sharma, A Soni… - Journal of Personalized …, 2022 - mdpi.com
Lung cancer is one of the most invasive cancers affecting over a million of the population.
Non-small cell lung cancer (NSCLC) constitutes up to 85% of all lung cancer cases, and …

Computational modeling to identify drugs targeting metastatic castration-resistant prostate cancer characterized by heightened glycolysis

MC Su, AM Lee, W Zhang, D Maeser, RF Gruener… - Pharmaceuticals, 2024 - mdpi.com
Metastatic castration-resistant prostate cancer (mCRPC) remains a deadly disease due to a
lack of efficacious treatments. The reprogramming of cancer metabolism toward elevated …

[HTML][HTML] Kinless hubs are potential target genes in prostate cancer network

IR Mangangcha, MZ Malik, O Kucuk, S Ali, RKB Singh - Genomics, 2020 - Elsevier
Complex disease networks can be studied successfully using network theoretical approach
which helps in finding key disease genes and associated disease modules. We studied …

Network medicine in ovarian cancer: topological properties to drug discovery

K Chirom, MZ Malik, IR Mangangcha… - Briefings in …, 2022 - academic.oup.com
Network medicine provides network theoretical tools, methods and properties to study
underlying laws governing human interactome to identify disease states and disease …

Identification of microRNA and gene interactions through bioinformatic integrative analysis for revealing candidate signatures in prostate cancer

MM Khan, M Serajuddin, MZ Malik - Gene Reports, 2022 - Elsevier
Abstract Background Prostate cancer (PCa) is a most common diagnosed cancer among
males globally. Despite the decreased PCa mortality, increased prevalence of it creates …

A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research

AK Ray, A Priya, MZ Malik, TA Thanaraj, AK Singh… - Scientific Reports, 2024 - nature.com
Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood
vessels. The molecular events and biochemical pathways associated with CVD are difficult …