JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …

Astrocytes play multiple important roles in brain physiology. In pathological conditions, they
become reactive, which is characterized by morphological changes and upregulation of …

One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where
the data only captures a small fraction of the transcriptome of each cell. Almost all …

Surface modification of tissue engineering scaffolds and substrates is required for improving
the efficacy of stem cell therapy by generating physicochemical stimulation promoting …

Neural stem cell (NSC)-based therapy is a promising candidate for treating
neurodegenerative diseases and the preclinical researches call an urgent need for …

Glioblastoma (GBM) is the most lethal primary brain tumor and is highly resistant to current
treatments. GBM harbors glioma stem cells (GSCs) that not only initiate and maintain …

The bone morphogenetic proteins (BMPs) are a group of potent morphogens which are
critical for the patterning, development, and function of the central nervous system. The …

Cytokines are involved in neural homeostasis and pathological processes associated with
neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including …

Myogenic differentiation plays an important role in muscle regeneration and is regulated by
two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …