Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Abstract The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of
essential signal transduction pathways in humans and other organisms that act as major …

Reelin, an extracellular protein essential for neural migration and lamination, is also
expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we …

Over half a century ago, DS Falconer first reported a mouse with a reeling gate. Four
decades later, the Reln gene was isolated and identified as the cause of the reeler …

The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain
lamination and normal dendritogenesis, but the specific mechanisms underlying these …

Reelin controls neuronal positioning in the developing brain by binding to the two
lipoprotein receptors, very-low-density lipoprotein receptor and apolipoprotein E receptor 2 …

The extracellular protein Reelin was initially identified as an essential factor in the control of
neuronal migration and layer formation in the developing mammalian brain. In the years …

The evolutionarily ancient low-density lipoprotein (LDL) receptor gene family represents a
class of widely expressed cell surface receptors. Since the dawn of the first primitive …