Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …

Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …

Background The variation in multiple sclerosis (MS) disease severity is incompletely
explained by genetics, suggesting genetic and environmental interactions are involved …

Methylation, a key epigenetic modification, is essential for regulating gene expression and
protein function without altering the DNA sequence, contributing to various biological …

Technologies for profiling samples using different omics platforms have been at the forefront
since the human genome project. Large-scale multi-omics data hold the promise of …

Epigenetic changes have been consistently detected in different cell types in multiple
sclerosis (MS). However, their contribution to MS pathogenesis remains poorly understood …

Vitamin D deficiency is a risk factor for developing multiple sclerosis (MS). However, the
immune effects of vitamin D in people with MS are not well understood. We analyzed …

Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune
system (immunosenescence) may be associated with disease onset or drive progression …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

Asthma is a complex trait, often associated with atopy. The genetic contribution has been
evidenced by familial occurrence. Genome-wide association studies allowed for associating …