Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology
J Plassais, J Kim, BW Davis, DM Karyadi… - Nature …, 2019 - nature.com
Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …
breed-associated behaviors resulting from human selective pressures. To identify the …
Murine axial compression tibial loading model to study bone mechanobiology: implementing the model and reporting results
RP Main, SJ Shefelbine, LB Meakin… - Journal of …, 2020 - Wiley Online Library
In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …
mechanotransduction. To achieve standardized and defined experimental conditions …
Using finite element modeling in bone mechanoadaptation
QA Meslier, SJ Shefelbine - Current osteoporosis reports, 2023 - Springer
Abstract Purpose of the Review Bone adapts structure and material properties in response
to its mechanical environment, a process called mechanoadpatation. For the past 50 years …
to its mechanical environment, a process called mechanoadpatation. For the past 50 years …
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia …
Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset
osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of …
osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of …
Adaptive changes in micromechanical environments of cancellous and cortical bone in response to in vivo loading and disuse
The skeleton accommodates changes in mechanical environments by increasing bone
mass under increased loads and decreasing bone mass under disuse. However, little is …
mass under increased loads and decreasing bone mass under disuse. However, little is …
Oral delivery of teriparatide using a nanoemulsion system: design, in vitro and in vivo evaluation
Purpose Investigate the possibility of delivering teriparatide orally using nanoemulsion.
Method Teriparatide was allowed to interact with chitosan in the presence of HPβCD. The …
Method Teriparatide was allowed to interact with chitosan in the presence of HPβCD. The …
Manipulating load-induced fluid flow in vivo to promote bone adaptation
QA Meslier, N DiMauro, P Somanchi, S Nano… - Bone, 2022 - Elsevier
Mechanical stimulation is critical to maintaining bone mass and strength. Strain has been
commonly thought of as the mechanical stimulus driving bone adaptation. However …
commonly thought of as the mechanical stimulus driving bone adaptation. However …
Interactive effects of various loading parameters on the fluid dynamics within the lacunar-canalicular system for a single osteocyte
The osteocyte lacunar-canalicular system (LCS) serves as a mechanotransductive core
where external loading applied to the skeleton is transduced into mechanical signals (eg …
where external loading applied to the skeleton is transduced into mechanical signals (eg …
Non-invasive prediction of the mouse tibia mechanical properties from microCT images: comparison between different finite element models
New treatments for bone diseases require testing in animal models before clinical
translation, and the mouse tibia is among the most common models. In vivo micro-Computed …
translation, and the mouse tibia is among the most common models. In vivo micro-Computed …
Cancellous bone may have a greater adaptive strain threshold than cortical bone
H Yang, WA Bullock, A Myhal… - Journal of Bone and …, 2021 - academic.oup.com
Strain magnitude has a controlling influence on bone adaptive response. However,
questions remain as to how and if cancellous and cortical bone tissues respond differently to …
questions remain as to how and if cancellous and cortical bone tissues respond differently to …