Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many
cancer‐related deaths. Over some years, chemotherapy, hormone treatment, radiation, and …

Glucose metabolism enzymes and transporters play major role in cancer development and
metastasis. In this study, we discuss glucose metabolism, transporters, receptors, hormones …

Background and Purpose: RAS mutations limit the effectiveness of anti-epidermal growth
factor receptor (EGFR) monoclonal antibodies in combination with chemotherapy for …

Abstract N6-methyladenosine (m6A) modification can alter gene expression by regulating
RNA splicing, stability, translocation, and translation. Emerging evidence shows that m6A …

The active ingredient of the traditional Chinese medicine comfrey is shikonin, a
naphthoquinone compound. The focus of this study was to investigate the effect of shikonin …

Natural products are important sources for drug discovery, especially anti-tumor drugs. β-
Elemene, the prominent active ingredient extract from the rhizome of Curcuma wenyujin, is a …

Abstract β-Elemene is a valuable sesquiterpene isolated from the essential oil of the
traditional Chinese medicine Curcuma wenyujin. As a Chinese class II non-cytotoxic …

Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the
conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level …

Introduction Elemene (C15H24) is a sesquiterpene compound extracted from the rhizome of
Curcuma herbs. In the past decades, the anti-tumor activity of elemene has been observed …

Tumor cells mainly provide necessary energy and substances for rapid cell growth through
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …