Predicting the effect of missense variations on protein stability and dynamics is important for
understanding their role in diseases, and the link between protein structure and function …

Abstract Changes in protein sequence can have dramatic effects on how proteins fold, their
stability and dynamics. Over the last 20 years, pioneering methods have been developed to …

Abstract Omicron, another SARS-CoV-2 variant, has been recorded and reported as a VoC.
It has already spread across> 30 countries and is a highly mutated variant. We tried to …

The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is responsible for the binding to the permissive cells. The receptor-binding domain (RBD) …

Regulation of amino acid's biosynthetic pathway is of significant importance to maintain
homeostasis and cell functions. Amino acids regulate their biosynthetic pathway by end …

Protein–protein interactions play a crucial role in all cellular functions and biological
processes and mutations leading to their disruption are enriched in many diseases. While a …

Significant efforts have been invested into understanding and predicting the molecular
consequences of mutations in protein coding regions, however nearly all approaches have …

Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy,
P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene …

While antibodies are becoming an increasingly important therapeutic class, especially in
personalized medicine, their development and optimization has been largely through …

The greatest challenge in drug discovery remains the high rate of attrition across the
different phases of the process, which cost the industry billions of dollars every year. While …