As a catalytic subunit of the positive transcription elongation factor b (P-TEFb), cyclin-
dependent kinase 9 (CDK9) has been demonstrated to contribute to carcinogenesis. This …

Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …

Rohitukine, a chromone alkaloid extracted from Dysoxylum binectariferum, has a propitious
anticancer activity. Our previous study shows that a new Rohitukine derivative IIIM‐290 …

The formation of new vessels requires a tight synchronization between proliferation,
differentiation, and sprouting. However, how these processes are differentially activated …

RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling.
We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling …

Abstract Background Cyclin-dependent kinases (CDKs) are protein kinases regulating
important cellular processes such as cell cycle and transcription. Many CDK genes also play …

Highlights•Modulation of pre-mRNA splicing is an effective alternative to the direct targeting
of proteins.•Insight into pre-mRNA splicing biology offers practical targeted strategies to …

P-TEFb and CDK12 facilitate transcriptional elongation by RNA polymerase II. Given the
prominence of both kinases in cancer, gaining a better understanding of their interplay could …

Abstract Cyclin-dependent kinase (CDK) 9 associates mainly with cyclin T1 and forms the
positive transcription elongation factor b (p-TEFb) complex responsible for transcriptional …

Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer with limited options for therapy. Cancer development and maintenance is …