The pandemic coronavirus disease 2019 (COVID‐19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS‐CoV‐2), has affected millions of people worldwide. To …

Concern that a highly pathogenic virus might cause the next influenza pandemic has
spurred recent research into influenza and its complications. Bacterial superinfection in the …

Secondary bacterial infections are a potentially fatal complication of influenza infection. We
aimed to define the impact of secondary bacterial infections on the clinical course and …

During respiration, humans breathe in more than 10,000 liters of non-sterile air daily,
allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar …

Infectious diseases have a profound impact on our health and many studies suggest that
host genetics play a major role in the pathogenesis of most of them. We perform 23 genome …

Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia,
particularly from Streptococcus pneumoniae. However, mechanisms underlying this …

Influenza A virus (IAV) infection triggers an exuberant host response that promotes acute
lung injury. However, the host response factors that promote the development of a …

Severe acute respiratory syndrome coronavirus (SARS-CoV-2), a novel corona virus,
causing COVID-19 with Flu-like symptoms is the first alarming pandemic of the third …

Respiratory tract infections are an important cause of morbidity and mortality worldwide.
Chief among these are infections involving the lower airways. The opportunistic bacterial …

Influenza is often complicated by bacterial pathogens that colonize the nasopharynx and
invade the middle ear and/or lung epithelium. Incidence and pathogenicity of influenza …