The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant
neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote …

Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

Diverse brain insults, including traumatic brain injury, stroke, infections, tumors,
neurodegenerative diseases, and prolonged acute symptomatic seizures, such as complex …

Descriptions of epileptic seizures and epilepsy date back to antiquity, and research into
fundamental mechanisms of epilepsy in animal models, as well as patients, has been …

BACKGROUND: Epilepsy appears in 70–80% of patients with tuberous sclerosis complex,
most commonly in the first year of age. Early manifestation of epilepsy is associated with …

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for
investigators who are searching for the most appropriate laboratory models to address key …