Skeletal muscle is the most abundant tissue in the human body and can adapt its mass as a
consequence of physical activity, metabolism, growth factors, and disease conditions …

Healthy aging requires the coordination of numerous stress signaling pathways that
converge on the protein homeostasis network. The integrated stress response (ISR) is …

Skeletal muscle is a highly plastic tissue in the human body that undergoes extensive
adaptation in response to environmental cues, such as physical activity, metabolic …

The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsible for
protein biosynthesis, folding, assembly and modifications. Loss of protein folding regulation …

Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of
patients with cancer. However, the mechanisms of cancer cachexia remain poorly …

The mitochondrial unfolded protein response (UPRmt) and mitophagy are two mitochondrial
quality control (MQC) systems that work at the molecular and organelle levels, respectively …

Sarcopenic obesity, which refers to concurrent sarcopenia and obesity, is characterized by
decreased muscle mass, strength, and performance along with abnormally excessive fat …

Skeletal muscle is an essential organ, responsible for many physiological functions such as
breathing, locomotion, postural maintenance, thermoregulation, and metabolism …

Skeletal muscle mass is regulated by the coordinated activation of several anabolic and
catabolic pathways. The endoplasmic reticulum (ER) is a major site of protein folding and a …

In different pathological situations, cardiac cells undergo hyperosmotic stress and cell
shrinkage. This change in cellular volume has been associated with contractile dysfunction …