The role of electron transfer dissociation in modern proteomics
(MS) and MS-driven proteomics have continued to develop as the premier tools for
characterizing proteome composition, structure, and function. 2 The new era of proteomics …
characterizing proteome composition, structure, and function. 2 The new era of proteomics …
Magnifying ion mobility spectrometry–mass spectrometry measurements for biomolecular structure studies
SN Majuta, H Maleki, AK Karanji, K Attanyake… - Current opinion in …, 2018 - Elsevier
Highlights•Application of ion mobility spectrometry–mass spectrometry (IMS–MS) techniques
for structure characterization have dramatically increased.•Growth is, in part, attributed to …
for structure characterization have dramatically increased.•Growth is, in part, attributed to …
In‐droplet hydrogen–deuterium exchange to examine protein/peptide solution conformer heterogeneity
Rationale Many different structure analysis techniques are not capable of probing the
heterogeneity of solution conformations. Here, we examine the ability of in‐droplet hydrogen …
heterogeneity of solution conformations. Here, we examine the ability of in‐droplet hydrogen …
Characterizing Multidevice Capillary Vibrating Sharp-Edge Spray Ionization for In-Droplet Hydrogen/Deuterium Exchange to Enhance Compound Identification
A DeBastiani, SN Majuta, D Sharif, K Attanayake… - ACS …, 2021 - ACS Publications
Multidevice capillary vibrating sharp-edge spray ionization (cVSSI) source parameters have
been examined to determine their effects on conducting in-droplet hydrogen/deuterium …
been examined to determine their effects on conducting in-droplet hydrogen/deuterium …
Evaluation of Hydrogen–Deuterium Exchange during Transient Vapor Binding of MeOD with Model Peptide Systems Angiotensin II and Bradykinin
The advancement of hybrid mass spectrometric tools as an indirect probe of molecular
structure and dynamics relies heavily upon a clear understanding between gas-phase ion …
structure and dynamics relies heavily upon a clear understanding between gas-phase ion …
Structure Characterization of a Disordered Peptide Using In-Droplet Hydrogen/Deuterium Exchange Mass Spectrometry and Molecular Dynamics
In-droplet hydrogen/deuterium exchange (HDX)-mass spectrometry (MS) experiments have
been conducted for peptides of highly varied conformational type. A new model is presented …
been conducted for peptides of highly varied conformational type. A new model is presented …
Comprehensive Peptide Ion Structure Studies Using Ion Mobility Techniques: Part 3. Relating Solution-Phase to Gas-Phase Structures
SG Kondalaji, M Khakinejad… - Journal of The American …, 2018 - ACS Publications
Molecular dynamics (MD) simulations have been utilized to study peptide ion conformer
establishment during the electrospray process. An explicit water model is used for …
establishment during the electrospray process. An explicit water model is used for …
Nucleation inhibition of Huntingtin protein (htt) by polyproline PPII helices: a potential interaction with the N-terminal α-helical region of htt
Huntington's disease is a genetic neurodegenerative disorder characterized by the
formation of amyloid fibrils of the huntingtin protein (htt). The 17-residue N-terminal region of …
formation of amyloid fibrils of the huntingtin protein (htt). The 17-residue N-terminal region of …
Comparison of peptide ion conformers arising from non-helical and helical peptides using ion mobility spectrometry and gas-phase hydrogen/deuterium exchange
AK Karanji, M Khakinejad, SG Kondalaji… - Journal of the …, 2018 - ACS Publications
The dominant gas-phase conformer of [M+ 3H] 3+ ions of the model peptide acetyl-
PSSSSKSSSSKSSSSKSSSSK has been examined with ion mobility spectrometry (IMS), gas …
PSSSSKSSSSKSSSSKSSSSK has been examined with ion mobility spectrometry (IMS), gas …
Investigating the interactions of the first 17 amino acid residues of Huntingtin with lipid vesicles using mass spectrometry and molecular dynamics
The first 17 amino acid residues of Huntingtin protein (Nt17 of htt) are thought to play an
important role in the protein's function; Nt17 is one of two membrane binding domains in htt …
important role in the protein's function; Nt17 is one of two membrane binding domains in htt …