Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

INTRODUCTION Influenza virus infects the epithelial cells that line the respiratory tract.
Therefore, cytotoxic CD8+ T cells must traffic to this site to eliminate infected cells. The …

Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …

Numerous reports document the role of vascular adhesion molecules in the development
and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules …

Selectins are carbohydrate-binding molecules that bind to fucosylated and sialylated
glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They are …

Platelets are essential for primary hemostasis, but they also play an important pro-
inflammatory role. Platelets normally circulate in a quiescent state. Upon activation, platelets …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes,
hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury …