Salamanders, such as axolotls and newts, can regenerate complex tissues including entire
limbs. But what mechanisms ensure that an amputated limb regenerates a limb, and not a …

Cellular reprogramming is characterized by the induced dedifferentiation of mature cells into
a more plastic and potent state. This process can occur through artificial reprogramming …

Salamanders are able to regenerate their entire limbs throughout lifespan, through a
process that involves significant modulation of cellular plasticity. Limb regeneration is …

Axolotl limb regeneration is accompanied by the transient induction of cellular senescence
within the blastema, the structure that nucleates regeneration. The precise role of this …

Abstract The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing
the basis of regeneration. Here, we present the sequencing and chromosome-scale …

The ability to generate transgenic animals sparked a wave of research committed to
implementing such technology in a wide variety of model organisms. Building a solid base of …

The salamander limb regenerates only the missing portion. Each limb segment can only
form segments equivalent to-or more distal to their own identity, relying on a property termed …

Upon limb amputation in salamanders, anterior and posterior connective tissue cells form
distinct signalling centres that together fuel successful regeneration. The molecular …

Background The regenerative capacity of organisms declines throughout evolution, and
mammals lack the ability to regenerate limbs after injury. Past approaches to achieving …

We know little about the control of positional information (PI) during axolotl limb
regeneration, which ensures that the limb regenerates exactly what was amputated, and the …