We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …

Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Background: The dopaminergic system has been associated with the progression of
Alzheimer's disease. But previous studies found inconsistent results regarding the …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Background Many studies have indicated that a history of depression increases the risk of
developing Alzheimer's disease (AD); however, the potential pathogenestic mechanism by …

Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi
apparatus, such as fragmentation, which is found, along with cognitive impairment, in …

The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by the aggregation of β-amyloid (Aβ) and tau in the brain. Breakthroughs in …