Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …

While considerable effort has been made to investigate the neural mechanisms of pain,
much less effort has been devoted to itch, at least until recently. However, itch is now gaining …

Itch and pain are closely related but distinct sensations. They share largely overlapping
mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch …

Itch and pain are distinct unpleasant sensations that can be triggered from the same
receptive fields in the skin, raising the question of how pruriception and nociception are …

Biological differences in sensory processing between human and model organisms may
present significant obstacles to translational approaches in treating chronic pain. To better …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …

Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …