Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis
is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three …

Carcinoma cells undergo epithelial-mesenchymal transition (EMT); however, contributions
of EMT heterogeneity to disease progression remain a matter of debate. Here, we …

Breast tumors are inherently heterogeneous, but the evolving cellular organization through
neoplastic progression is poorly understood. Here we report a rapid, large-scale single-cell …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

The circulating tumor cells (CTCs, the root cause of cancer metastasis and poor cancer
prognosis) are very difficult to culture for scale-up in vitro, which has hampered their use in …

Tumor cells demonstrate substantial plasticity in their genotypic and phenotypic
characteristics. Epithelial-mesenchymal plasticity (EMP) can be characterized into dynamic …