TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
[HTML][HTML] H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation
Cell fate determination is an intricate process which is orchestrated by multiple regulatory
layers including signal pathways, transcriptional factors, epigenetic modifications, and …
layers including signal pathways, transcriptional factors, epigenetic modifications, and …
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
Summary METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …
ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1
The progression from naive through formative to primed in vitro pluripotent stem cell states
recapitulates epiblast development in vivo during the peri-implantation period of mouse …
recapitulates epiblast development in vivo during the peri-implantation period of mouse …
Role of RNA binding proteins of the Drosophila behavior and human splicing (DBHS) family in health and cancer
T Takeiwa, K Ikeda, K Horie, S Inoue - RNA biology, 2024 - Taylor & Francis
ABSTRACT RNA-binding proteins (RBPs) play crucial roles in the functions and
homoeostasis of various tissues by regulating multiple events of RNA processing including …
homoeostasis of various tissues by regulating multiple events of RNA processing including …
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations
A Fleming, EV Knatko, X Li, A Zoch… - Genes & …, 2024 - genesdev.cshlp.org
The link between DNA methylation and neurodevelopmental disorders is well established.
However, how DNA methylation is fine-tuned—ensuring precise gene expression and …
However, how DNA methylation is fine-tuned—ensuring precise gene expression and …
[HTML][HTML] The lncRNA Neat1 is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer's disease
Dysregulation of long non-coding RNAs (lncRNAs) have been associated with Alzheimer's
disease (AD). However, the functional role of lncRNAs in AD remains unclear. Here, we …
disease (AD). However, the functional role of lncRNAs in AD remains unclear. Here, we …
TET1 Catalytic activity is required for reprogramming of imprinting control regions and patterning of sperm-specific hypomethylated regions
RD Prasasya, BA Caldwell, Z Liu, S Wu, NA Leu… - bioRxiv, 2023 - biorxiv.org
SUMMARY DNA methylation erasure is required for mammalian primordial germ cell
reprogramming. TET enzymes iteratively oxidize 5-methylcytosine to generate 5 …
reprogramming. TET enzymes iteratively oxidize 5-methylcytosine to generate 5 …
The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation
The transition of embryonic stem cells (ESCs) from pluripotency to lineage commitment is
regulated by multiple mechanisms, including chromatin dynamics and both transcriptional …
regulated by multiple mechanisms, including chromatin dynamics and both transcriptional …