The genetics of rheumatoid arthritis
LE Dedmon - Rheumatology, 2020 - academic.oup.com
RA is a chronic systemic inflammatory disease that primarily affects the small joints of the
hands and feet, and results in a mean reduction in life expectancy of 3–10 years. RA is a …
hands and feet, and results in a mean reduction in life expectancy of 3–10 years. RA is a …
[HTML][HTML] Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity?
Methotrexate (MTX) is the anchor disease-modifying antirheumatic drug (DMARD) in
rheumatoid arthritis (RA) treatment. It is used in monotherapy and/or in combination with …
rheumatoid arthritis (RA) treatment. It is used in monotherapy and/or in combination with …
Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update
H Zhu, FY Deng, XB Mo, YH Qiu, SF Lei - Pharmacogenomics, 2014 - Future Medicine
Rheumatoid arthritis (RA) is a complex, systemic autoimmune disease characterized by
chronic inflammation of multiple peripheral joints, which leads to serious destruction of …
chronic inflammation of multiple peripheral joints, which leads to serious destruction of …
Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis
Q Qiu, J Huang, Y Lin, X Shu, H Fan, Z Tu, Y Zhou… - Medicine, 2017 - journals.lww.com
Background: Methotrexate (MTX) is widely used and considered a first-line disease
modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA) …
modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA) …
SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients
Methotrexate (MTX) is used for rheumatoid arthritis (RA) treatment showing a wide toxicity
profile. This study aimed to evaluate the influence of single nucleotide polymorphisms …
profile. This study aimed to evaluate the influence of single nucleotide polymorphisms …
The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta …
Methotrexate (MTX), the most commonly used anti-rheumatic drug against RA, enters the
cell via the action of the reduced folate carrier 1 (RFC1). A major polymorphism of the RFC1 …
cell via the action of the reduced folate carrier 1 (RFC1). A major polymorphism of the RFC1 …
Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therapeutic outcome
Aim: Evaluate the potential of selected SNPs as predictors of methotrexate (MTX)
therapeutic outcome. Patients & methods: In total, 35 SNPs in 14 genes involved in MTX …
therapeutic outcome. Patients & methods: In total, 35 SNPs in 14 genes involved in MTX …
[HTML][HTML] Pharmacogenomics of methotrexate membrane transport pathway: can clinical response to methotrexate in rheumatoid arthritis be predicted?
Background: Methotrexate (MTX) is widely used for rheumatoid arthritis (RA) treatment.
Single nucleotide polymorphisms (SNPs) could be used as predictors of patients' …
Single nucleotide polymorphisms (SNPs) could be used as predictors of patients' …
[HTML][HTML] MTHFR gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis based on 16 studies
Z Bagheri-Hosseinabadi, D Imani, H Yousefi… - Clinical …, 2020 - Springer
Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease, in which an
epigenetic implication in the disease etiopathogenesis has been noted. Here in this meta …
epigenetic implication in the disease etiopathogenesis has been noted. Here in this meta …
Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia
Y Zhou, H He, L Ding, T Wang, X Liu, M Zhang… - European Journal of …, 2024 - Springer
This study aims to assess the role of methotrexate-related gene polymorphisms in children
with acute lymphoblastic leukemia (ALL) during high-dose methotrexate (HD-MTX) therapy …
with acute lymphoblastic leukemia (ALL) during high-dose methotrexate (HD-MTX) therapy …