Signal amplification strategies for DNA and protein detection based on polymeric nanocomposites and polymerization: A review

S Zhou, L Yuan, X Hua, L Xu, S Liu - Analytica Chimica Acta, 2015 - Elsevier
Demand is increasing for ultrasensitive bioassays for disease diagnosis, environmental
monitoring and other research areas. This requires novel signal amplification strategies to …

Glucose oxidase‐mediated polymerization as a platform for dual‐mode signal amplification and biodetection

BJ Berron, LM Johnson, X Ba, JD McCall… - Biotechnology and …, 2011 - Wiley Online Library
We report the first use of a polymerization‐based ELISA substrate solution employing
enzymatically mediated radical polymerization as a dual‐mode amplification strategy …

Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings

JL Lilly, A Gottipati, CF Cahall, M Agoub, BJ Berron - PloS one, 2018 - journals.plos.org
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation
technologies. While eosin is used in conjunction with tertiary amines as a water-soluble …

Investigation of dendrimers functionalized with eosin as macrophotoinitiators for polymerization-based signal amplification reactions

K Kaastrup, HD Sikes - RSC Advances, 2015 - pubs.rsc.org
Polymerization-based signal amplification, a technique developed for use in rapid
diagnostic tests, hinges on the ability to localize initiators as a function of interfacial binding …

Impact of Dissociation Constant on the Detection Sensitivity of Polymerization-Based Signal Amplification Reactions

K Kaastrup, L Chan, HD Sikes - Analytical Chemistry, 2013 - ACS Publications
Many studies have demonstrated the concept of using free-radical polymerization reactions
to provide signal amplification so that molecular recognition events indicative of disease …

Antigen-responsive, microfluidic valves for single use diagnostics

BJ Berron, AM May, Z Zheng, V Balasubramaniam… - Lab on a Chip, 2012 - pubs.rsc.org
The growing need for medical diagnostics in resource limited settings is driving the
development of simple, standalone immunoassay devices. A capillary flow device using …

[HTML][HTML] Low-cost plug and play photochemistry reactor

D Dellal, E Yee, S Lathwal, H Sikes, J Gomez-Marquez - HardwareX, 2018 - Elsevier
Polymerization-based amplification (PBA) uses a visible-light photopolymerization reaction
for rapid, low-cost signal amplification and colorimetric detection in disease diagnostics …

[HTML][HTML] Photoinitiator nucleotide for quantifying nucleic acid hybridization

LM Johnson, RR Hansen, M Urban, RD Kuchta… - …, 2010 - ncbi.nlm.nih.gov
This first report of a photoinitiator-nucleotide conjugate demonstrates a novel approach for
sensitive, rapid and visual detection of DNA hybridization events. This approach holds …

Interfacial polymerization for colorimetric labeling of protein expression in cells

JL Lilly, PR Sheldon, LJ Hoversten, G Romero… - PloS one, 2014 - journals.plos.org
Determining the location of rare proteins in cells typically requires the use of on-sample
amplification. Antibody based recognition and enzymatic amplification is used to produce …

Photopolymerization-based signal amplification: mechanistic characterization and practical implementation

K Kaastrup - 2015 - dspace.mit.edu
Polymerization-based signal amplification is an approach to biosensing that leverages the
amplification inherent to radical polymerization to enhance signal associated with molecular …