The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …

Simple Summary Colorectal cancer is one of the most prevalent neoplasms worldwide.
Capecitabine is an oral fluoropyrimidine widely used to treat colorectal cancer in early and …

头颈部恶性肿瘤患者肿瘤药物敏感性检测的临床意义- PMC Back to Top Skip to main content NIH
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Exosome-mediated microRNA transfer has been shown to regulate cancer progression.
However, the involvement of exosomal-miR-506-3p in colorectal cancer (CRC) is unknown …

Background: Accumulated evidence shows that DNA repair gene X-ray repair cross
complementing group 1 (XRCC1) may determine individual susceptibility to head and neck …

Hand-Foot syndrome (HFS) and diarrhoea are dose-limiting Adverse Drug Reactions
(ADRs) of capecitabine-based chemotherapy. Four polymorphisms in the dihydropyrimidine …

Objective (s): Colorectal cancer is the second deadly cancer for men and women worldwide.
Depending on the pathological attributes of the tumor, there are numerous therapeutic …

Capecitabine is a widely-used antineoplastic drug, a prodrug to 5-fluorouracil which
commonly induces gastrointestinal toxicity. Enterocolitis, as a rarely recognized …

The relationship between single nucleotide polymorphisms (SNPs) at various loci and
adverse drug reactions (ADRs) in patients with gynecologic cancer receiving platinum …

Purpose Fluoropyrimidines, the major chemotherapeutic agents in various malignancies
treatment, are metabolized by dihydropyrimidine dehydrogenase (DPD). DPD deficiency …