One hundred years after its discovery, insulin remains the life-saving therapy for many
patients with diabetes. It has been a 100-years-old success story thanks to the fact that …

Abstract β-cell replacement via islet transplantation (IT) is a viable option for the
management of patients with type 1 diabetes. Despite good functional results, IT remains …

Islet transplantation (ITx) is an established and safe alternative to pancreas transplantation
for type 1 diabetes mellitus (T1DM) patients. However, most ITx recipients lose insulin …

Pediatric donors are underutilized for simultaneous pancreas-kidney transplantation due to
concerns about technical complications and inadequate islet and/or renal mass. We …

Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a
substantial economic burden on healthcare globally. A century has passed since the …

糖尿病发病率呈上升趋势, 临床治疗极具挑战性. 虽然药物降糖具有一定疗效,
但存在血糖波动的危险, 1 型糖尿病的临床治愈仍难以实现. 胰岛细胞移植是解决胰岛素注射 …

Pancreatic transplantation is the only treatment for insulin‐dependent diabetes resulting in
long‐term euglycemia without exogenous insulin. However, pancreatic transplantation has …

Regenerative medicine is set to revolutionize the treatment of type 1 diabetes. Using cell-
based technologies, it seeks to restore within the patient's body the function of pancreatic …

Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Type 1 diabetes mellitusaffects 45 million people worldwide and its prevalence is rapidly
increasing. This chronic metabolic disease derives from a lack of insulin production by the …