The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Intraocular pressure (IOP) is the most important modifiable risk factor for glaucoma and
fluctuates considerably within patients over short and long time periods. Our field's …

GPR18 is a G-protein-coupled receptor that belongs to the orphan class A family. Even
though it shares low sequence homology with the cannabinoid receptors CB1R and CB2R …

Purpose: It has been known for nearly 50 years that cannabis and the psychoactive
constituent Δ 9-tetrahydrocannabinol (THC) reduce intraocular pressure (IOP). Elevated IOP …

Epilepsy contributes to approximately 1% of the global disease burden. By affecting
especially young children as well as older persons of all social and racial variety, epilepsy is …

Saliva serves multiple important functions within the body that we typically take for granted,
such as helping prepare food for swallowing and defense against oral pathogens. Dry …

GPR18, still considered an orphan receptor, may respond to endocannabinoids, whose
canonical receptors are CB 1 and CB 2. GPR18 and CB 2 receptors share a role in …

Cannabidiol (CBD) is a phytocannabinoid that has a great clinical therapeutic potential. Few
studies have been published on its efficacy in ocular inflammations while its impact on …

Introduction Glaucoma, a neuropathy characterized by increased intraocular pressure (IOP),
is the major cause of blindness worldwide and its treatment aims at reducing IOP. Areas …