Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Enzyme therapy: current challenges and future perspectives

M de la Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …

Oxygen, reactive oxygen species and tissue damage

CM Bergamini, S Gambetti, A Dondi… - Current …, 2004 - ingentaconnect.com
The diatomic molecule of oxygen contains two uncoupled electrons and can therefore
undergo reduction, yielding several different oxygen metabolites, which are collectively …

The role of oxidative damage and stress in aging

A Bokov, A Chaudhuri, A Richardson - Mechanisms of ageing and …, 2004 - Elsevier
The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is
currently one of the most popular explanations for how aging occurs at the …

Superoxide dismutases and their impact upon human health

F Johnson, C Giulivi - Molecular aspects of medicine, 2005 - Elsevier
Superoxide dismutases (SOD), a group of metal-containing enzymes, have a vital anti-
oxidant role in human health, conferred by their scavenging of one of the reactive oxygen …

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

P Kirkham, I Rahman - Pharmacology & therapeutics, 2006 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases
that are characterized by systemic and chronic localized inflammation and oxidative stress …

Breath analysis: potential for clinical diagnosis and exposure assessment

W Cao, Y Duan - Clinical chemistry, 2006 - academic.oup.com
Breath tests are among the least invasive methods available for clinical diagnosis, disease
state monitoring, and environmental exposure assessment. In recent years, interest in breath …

Enzymes for pharmaceutical and therapeutic applications

GK Meghwanshi, N Kaur, S Verma… - Biotechnology and …, 2020 - Wiley Online Library
Enzymes are highly efficient and selective biocatalysts, present in the living beings. They
exist in enormous varieties in terms of the types of reactions catalyzed by them for instance …

Metal coordination complexes as therapeutic agents for ischemia-reperfusion injury

NP Bigham, JJ Wilson - Journal of the American Chemical Society, 2023 - ACS Publications
Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

The enzyme as drug: application of enzymes as pharmaceuticals

M Vellard - Current opinion in biotechnology, 2003 - Elsevier
Enzymes as drugs have two important features that distinguish them from all other types of
drugs. First, enzymes often bind and act on their targets with great affinity and specificity …