Innate immunity represents the first line of defence against invading pathogens. It consists of
an initial inflammatory response that recruits white blood cells to the site of infection in an …

Ubiquitination is a post‐translational modification process that has been implicated in the
regulation of innate and adaptive immune responses. There is increasing evidence that both …

Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the
spotlight, as loci associated with AD risk are enriched in genes expressed in microglia …

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …

Many autoreactive B cells persist in the periphery in a state of unresponsiveness called
anergy. This unresponsiveness is rapidly reversible, requiring continuous BCR interaction …

In the past five years, a series of large-scale genetic studies have revealed novel risk factors
for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the …

X‐linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro‐inflammatory
signalling downstream of the nucleotide‐binding oligomerization domain containing (NOD) …

X-linked lymphoproliferative syndrome (XLP) is a rare primary immunodeficiency
characterized by increased vulnerability to Epstein–Barr virus infection. XLP type 1 is …

The inhibitor of apoptosis (IAP) family members, notably cIAP1, cIAP2, and XIAP, are critical
and universal regulators of tumor necrosis factor (TNF) mediated survival, inflammatory, and …

The innate immune system is composed of a wide repertoire of conserved pattern
recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in …