On the road to the brain-on-a-chip: a review on strategies, methods, and applications

M Brofiga, M Pisano, R Raiteri… - Journal of Neural …, 2021 - iopscience.iop.org
The brain is the most complex organ of our body. Such a complexity spans from the single-
cell morphology up to the intricate connections that hundreds of thousands of neurons …

Emerging brain‐pathophysiology‐mimetic platforms for studying neurodegenerative diseases: brain organoids and brains‐on‐a‐chip

S Bang, S Lee, N Choi, HN Kim - Advanced Healthcare …, 2021 - Wiley Online Library
Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …

Neurohybrid memristive CMOS-integrated systems for biosensors and neuroprosthetics

A Mikhaylov, A Pimashkin, Y Pigareva… - Frontiers in …, 2020 - frontiersin.org
Here we provide a perspective concept of neurohybrid memristive chip based on the
combination of living neural networks cultivated in microfluidic/microelectrode system, metal …

Brain-on-a-chip: A history of development and future perspective

S Bang, S Jeong, N Choi, HN Kim - Biomicrofluidics, 2019 - pubs.aip.org
Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …

Modular microstructure design to build neuronal networks of defined functional connectivity

C Forró, G Thompson-Steckel, S Weaver… - Biosensors and …, 2018 - Elsevier
Theoretical and in vivo neuroscience research suggests that functional information transfer
within neuronal networks is influenced by circuit architecture. Due to the dynamic …

Impact of microchannel width on axons for brain-on-chip applications

K Vulić, G Amos, T Ruff, R Kasm, SJ Ihle, J Küchler… - Lab on a Chip, 2024 - pubs.rsc.org
Technologies for axon guidance for in vitro disease models and bottom up investigations are
increasingly being used in neuroscience research. One of the most prevalent patterning …

[HTML][HTML] Engineered neural circuits for modeling brain physiology and neuropathology

S Bang, KS Hwang, S Jeong, IJ Cho, N Choi, J Kim… - Acta Biomaterialia, 2021 - Elsevier
The neural circuits of the central nervous system are the regulatory pathways for feeling,
motion control, learning, and memory, and their dysfunction is closely related to various …

Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity

N Winter-Hjelm, ÅB Tomren, P Sikorski… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Microfluidic devices interfaced with microelectrode arrays have in recent years
emerged as powerful platforms for studying and manipulating in vitro neuronal networks at …

Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction

KS Hanssen, N Winter-Hjelm, SN Niethammer… - Scientific Reports, 2024 - nature.com
Engineered biological neural networks are indispensable models for investigation of neural
function and dysfunction from the subcellular to the network level. Notably, advanced …

[HTML][HTML] Brain physiome: A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

Y Seo, S Bang, J Son, D Kim, Y Jeong, P Kim, J Yang… - Bioactive Materials, 2022 - Elsevier
In the last few decades, adverse reactions to pharmaceuticals have been evaluated using
2D in vitro models and animal models. However, with increasing computational power, and …