Nucleic acids: function and potential for abiogenesis
F Wachowius, J Attwater, P Holliger - Quarterly Reviews of …, 2017 - cambridge.org
The emergence of functional cooperation between the three main classes of biomolecules–
nucleic acids, peptides and lipids–defines life at the molecular level. However, how such …
nucleic acids, peptides and lipids–defines life at the molecular level. However, how such …
Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying
2-Thiouridine (s2U) is a nucleobase modification that confers enhanced efficiency and
fidelity both on modern tRNA codon translation and on nonenzymatic and ribozyme …
fidelity both on modern tRNA codon translation and on nonenzymatic and ribozyme …
Prebiotic synthesis and triphosphorylation of 3′-amino-TNA nucleosides
D Whitaker, MW Powner - Nature Chemistry, 2022 - nature.com
Nucleosides are essential to the emergence of life, and so their synthesis is a key challenge
for prebiotic chemistry. Although amino-nucleosides have enhanced reactivity in water …
for prebiotic chemistry. Although amino-nucleosides have enhanced reactivity in water …
[PDF][PDF] Deep sequencing of non-enzymatic RNA primer extension
D Duzdevich, CE Carr, JW Szostak - Nucleic acids research, 2020 - academic.oup.com
Life emerging in an RNA world is expected to propagate RNA as hereditary information,
requiring some form of primitive replication without enzymes. Non-enzymatic template …
requiring some form of primitive replication without enzymes. Non-enzymatic template …
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension
Nonenzymatic copying of RNA templates with activated nucleotides is a useful model for
studying the emergence of heredity at the origin of life. Previous experiments with defined …
studying the emergence of heredity at the origin of life. Previous experiments with defined …
Nucleotide Photochemistry on the Early Earth
DE Whitaker, BWF Colville… - Conflicting Models for the …, 2023 - Wiley Online Library
The photochemistry of nucleic acids has been a topic of extensive research for more than
half a century [15.163] due to the relationship between ultraviolet light and human disease …
half a century [15.163] due to the relationship between ultraviolet light and human disease …
Studies towards the prebiotic synthesis of nucleotides and amino acids
K Ashe - 2018 - discovery.ucl.ac.uk
Understanding how life on Earth might have started is the major goal of prebiotic chemistry.
The universal nature of extant life, with integrated informational, catalytic and compartment …
The universal nature of extant life, with integrated informational, catalytic and compartment …