The trypanosomiases consist of a group of important animal and human diseases caused by
parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the …

Leishmaniasis is a major public health problem and till date there are no effective vaccines
available. The control strategy relies solely on chemotherapy of the infected people …

Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid
protozoa because this pathway plays an essential role in their ATP supply. Trypanosomatid …

Can we consider cancer to be a “metabolic disease”? Tumors are the result of a metabolic
selection, forming tissues composed of heterogeneous cells that generally express an …

Two approaches to structure-based drug design, that is, the docking of known compounds
into a target protein and molecular assembly in situ, are seen to be merging technologies …

Ligand flexibility is an important problem in molecular docking and virtual screening. To
address this challenge, we investigate a hierarchical pre-organization of multiple …

GAPDH (d-glyceraldehyde-3-phosphate dehydrogenase) is a multifunctional protein that is
a target for the design of antitrypanosomatid and anti-apoptosis drugs. Here, the first high …

The parasitic protists of the Trypanosoma genus infect humans and domestic mammals,
causing severe mortality and huge economic losses. The most threatening trypanosomiasis …

The progresses made in the field of drug design to combat tropical protozoan parasitic
diseases, such as Chagas' disease, leishmaniasis, and sleeping sickness are discussed …