Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell
function, is emerging as an important factor in many inflammatory diseases. Mechano …

The lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights
into the cell lineage relationships during tissue morphogenesis. However, little is known …

Chloride intracellular channels (CLICs) are a family of proteins that exist in soluble and
transmembrane forms. The newest discovered member of the family CLIC6 is implicated in …

Abstract Chloride Intracellular Channel (CLIC) family members uniquely transition between
soluble and membrane-associated conformations. Despite decades of extensive functional …

The marginal stability of globular proteins in the cell is determined by the balance between
excluded volume effect and soft interactions. Quinary interactions are a type of soft …

Simple Summary Although chloride intracellular channel proteins (CLICs) have been
identified as ion channel proteins, their true functions are still elusive. Recent in silico …

Technology to generate single cell RNA-sequencing (scRNA-seq) datasets and tools to
annotate them have advanced rapidly in the past several years. Such tools generally rely on …

Despite significant advances in targeted and immune therapy for non-small cell lung cancer
(NSCLC), effective therapies for wild-type epidermal growth factor receptor/anaplastic …

Background Sterols have been reported to modulate conformation and hence the function of
several membrane proteins. One such group is the Chloride Intracellular Ion Channel (CLIC) …

Fuchs' endothelial corneal dystrophy (FECD) is a progressive vision impairing disease
caused by thickening of Descemet's membrane and gradual degeneration and loss of …