Aims Statin intolerance (SI) represents a significant public health problem for which precise
estimates of prevalence are needed. Statin intolerance remains an important clinical …

Abstract The Committee of Clinical Practice Guidelines of the Korean Diabetes Association
(KDA) updated the previous clinical practice guidelines for Korean adults with diabetes and …

Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers.
Consistent basic data suggest that these same checkpoints are critical negative regulators of …

Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in
water or in lipid-containing media. The predominantly lipophilic statins (simvastatin …

Importance Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive
statin therapy reduces progression of coronary atherosclerosis in proportion to achieved …

Over the last 3 decades there have been substantial improvements in treatments aimed at
reducing cardiovascular (CV) events. As these treatments have been developed, there have …

Diabetes mellitus is a complex, chronic illness requiring continuous medical care with
multifactorial risk reduction strategies beyond glycemic control. Ongoing patient self …

Background: Statins can regress coronary atheroma and lower clinical events. Although pre-
clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can …