Sterols associate preferentially with plasma membrane sphingolipids and saturated
phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity …

The cellular plasma membrane serves as a portal for the entry of intracellular pathogens. An
essential step for an intracellular pathogen to gain entry into a host cell therefore is to be …

Leishmania donovani is an intracellular protozoan parasite that causes visceral
leishmaniasis, a major cause of mortality and morbidity worldwide. The host plasma …

Lipids form an integral, structural, and functional part of all life forms. They play a significant
role in various cellular processes such as membrane fusion, fission, endocytosis, protein …

The biosynthesis of cholesterol, an essential component of higher eukaryotic membranes,
was worked out by Konrad Bloch (and Feodor Lynen) in the 1960s and they received the …

Leishmania are obligate intracellular protozoan parasites that invade and survive within host
macrophages leading to leishmaniasis, a major cause of mortality and morbidity worldwide …

Mycobacterium tuberculosis (M. tb) infection manifests into tuberculosis (TB) in a small
fraction of the infected population that comprises the TB susceptible group. Identifying the …

Lipids play a central role in many infectious diseases. AIDS (Acquired Immune Deficiency
Syndrome) and tuberculosis are two of the deadliest infectious diseases to have struck …

To increase our understanding of factors contributing to therapeutic failure (TF) in
leishmaniasis, we have studied some plasma membrane features of host THP-1 cells …

Cholesterol, an essential component of higher eukaryotic membranes, was discovered more
than two centuries ago. The development and progress of cholesterol research in the last …