Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation.
Background Epithelial-mesenchymal transformation (EMT) plays an important role in …

The insulin-like growth factor (IGF) system, consisting of IGF-I and IGF-II, their binding
proteins, and their receptors, is expressed in a spatial organization in the nephron, but …

Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized
rats. The 5/6 nephrectomy model is used to study pathogenetic mechanisms underlying …

Interferon-γ inhibits experimental renal fibrosis. Background Recent evidence has implicated
myofibroblasts as a cell type responsible for the laying down of extracellular matrix …

The role of EGF in the evolution of renal lesions after injury is still controversial. To
determine whether the EGF expression is beneficial or detrimental, we generated transgenic …

Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney.
Background Macrophage (Mφ) infiltration may contribute to chronic renal injury. We …

A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in
experimental glomerulonephritis. Background Although apoptosis has been linked to the …

This paper reviews some important recent findings on the molecular biology of the
peritoneal membrane. It attempts to correlate in vitro and in vivo experimental results with …

It was recently demonstrated that renal tissue transglutaminase (tTg) protein and its catalytic
product the ε (γ-glutamyl) lysine protein cross-link are significantly increased in the subtotal …

Advanced glycation end products (AGE), growth factors, and nitric oxide contribute to
alterations of the peritoneum during peritoneal dialysis (PD). These mediators are also …