Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Development of fluorescence polarization (FP) assays, especially in a competitive manner,
is a potent and mature tool for measuring the binding affinities of small molecules. This …

Conspectus Rigorous substrate selectivity is a hallmark of enzyme catalysis. This selectivity
is generally ascribed to a thermodynamically favorable process of substrate binding to the …

The hypoxia-inducible factors are α, β-heterodimeric transcription factors that mediate the
chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging …

The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl
hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms …

Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe (II)-
dependent oxygenase that catalyzes hydroxylation of specific asparagines in the C-terminal …

Objective Ferroptosis is an iron-dependent nonapoptotic form of cell death, characterized by
iron accumulation and lipid peroxidation. However, the role of ferroptosis in methylmercury …

Cancer stem cells (CSCs) are subpopulations in the malignant tumors that show self-
renewal and multilineage differentiation into tumor microenvironment components that drive …

Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily
detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S …

This study investigates dioxygen binding and 2‐oxoglutarate (2OG) coordination by two
model non‐heme FeII/2OG enzymes: a class 7 histone demethylase (PHF8) that catalyzes …