Mitochondria and the autophagy–inflammation–cell death axis in organismal aging
Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases.
As mitochondria age in our cells, they become progressively inefficient and potentially toxic …
As mitochondria age in our cells, they become progressively inefficient and potentially toxic …
Receptor-mediated mitophagy in yeast and mammalian systems
Mitophagy, or mitochondria autophagy, plays a critical role in selective removal of damaged
or unwanted mitochondria. Several protein receptors, including Atg32 in yeast, NIX/BNIP3L …
or unwanted mitochondria. Several protein receptors, including Atg32 in yeast, NIX/BNIP3L …
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial Membrane*♦
SR Yoshii, C Kishi, N Ishihara, N Mizushima - Journal of Biological …, 2011 - ASBMB
Upon mitochondrial depolarization, Parkin, a Parkinson disease-related E3 ubiquitin ligase,
translocates from the cytosol to mitochondria and promotes their degradation by mitophagy …
translocates from the cytosol to mitochondria and promotes their degradation by mitophagy …
Protecting the mitochondrial powerhouse
Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu
for the synthesis of many essential molecules and allow for highly efficient energy …
for the synthesis of many essential molecules and allow for highly efficient energy …
The role and mechanism of SIRT1 in resveratrol-regulated osteoblast autophagy in osteoporosis rats
X Yang, T Jiang, Y Wang, L Guo - Scientific reports, 2019 - nature.com
Osteoporosis is widely regarded as one of the typical aging-related diseases due to the
impairment of bone remodeling. The silent information regulator of transcription1 (SIRT1) is …
impairment of bone remodeling. The silent information regulator of transcription1 (SIRT1) is …
A stress-responsive system for mitochondrial protein degradation
We show that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive—
Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the …
Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the …
Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
Aging is characterized by the accumulation of damaged cellular macromolecules caused by
declining repair and elimination pathways. An integral component employed by cells to …
declining repair and elimination pathways. An integral component employed by cells to …
Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction
Autophagy is a highly-conserved cellular degradation and recycling system that is essential
for cell survival during nutrient starvation. The loss of viability had been used as an initial …
for cell survival during nutrient starvation. The loss of viability had been used as an initial …
[HTML][HTML] Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and …
JK Ngo, LCD Pomatto, KJA Davies - Redox biology, 2013 - Elsevier
The elimination of oxidatively modified proteins is a crucial process in maintaining cellular
homeostasis, especially during stress. Mitochondria are protein-dense, high traffic …
homeostasis, especially during stress. Mitochondria are protein-dense, high traffic …
Interplays of AMPK and TOR in autophagy regulation in yeast
Cells survey their environment and need to balance growth and anabolism with stress
programmes and catabolism towards maximum cellular bioenergetics economy and …
programmes and catabolism towards maximum cellular bioenergetics economy and …