RNA out of the mist
JS Mattick - Trends in Genetics, 2023 - cell.com
RNA has long been regarded primarily as the intermediate between genes and proteins. It
was a surprise then to discover that eukaryotic genes are mosaics of mRNA sequences …
was a surprise then to discover that eukaryotic genes are mosaics of mRNA sequences …
Cell type–specific analysis by single-cell profiling identifies a stable mammalian tRNA–mRNA interface and increased translation efficiency in neurons
The correlation between codon and anticodon pools influences the efficiency of translation,
but whether differences exist in these pools across individual cells is unknown. We …
but whether differences exist in these pools across individual cells is unknown. We …
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner
QP Xiong, J Li, H Li, ZX Huang, H Dong… - Science China Life …, 2023 - Springer
TRMT1 is an N 2-methylguanosine (m2G) and N 2, N 2-methylguanosine (m22G)
methyltransferase that targets G26 of both cytoplasmic and mitochondrial tRNAs. In higher …
methyltransferase that targets G26 of both cytoplasmic and mitochondrial tRNAs. In higher …
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2–Related Genes in Kidney Renal Clear Cell Carcinoma
Y Huang, S Chen, L Xiao, W Qin, L Li… - … in Bioengineering and …, 2022 - frontiersin.org
Kidney renal clear cell carcinoma (KIRC) is a common aggressive malignancy of the urinary
system. COVID-19, a highly infectious and severe disease caused by SARS-CoV-2, has …
system. COVID-19, a highly infectious and severe disease caused by SARS-CoV-2, has …
Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease
K Zhang, P Eldin, JH Ciesla, L Briant, JM Lentini… - Elife, 2024 - elifesciences.org
Abstract Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves
viral polyproteins into individual polypeptides necessary for viral replication. Here, we show …
viral polyproteins into individual polypeptides necessary for viral replication. Here, we show …
Ontology specific alternative splicing changes in Alzheimer's disease
Y Lu, D Yue, J Xie, L Cheng, X Wang - Frontiers in Genetics, 2022 - frontiersin.org
Alternative splicing (AS) is a common phenomenon and correlates with aging and aging-
related disorders including Alzheimer's disease (AD). We aimed to systematically …
related disorders including Alzheimer's disease (AD). We aimed to systematically …
[HTML][HTML] Comprehensive characterization of small noncoding RNA profiles in hypoxia-induced pulmonary hypertension (HPH) rat tissues
J Wang, J Kuang, S Zhang, Z Liu, Q Guo, S Li, L Qiu… - Iscience, 2024 - cell.com
Hypoxia-induced pulmonary hypertension (HPH) is a fatal cardiovascular disease
characterized by an elevation in pulmonary artery pressure, resulting in right ventricular …
characterized by an elevation in pulmonary artery pressure, resulting in right ventricular …
N 2-methylguanosine and N 2, N 2-dimethylguanosine in cytosolic and mitochondrial tRNAs
J Petrosyan, KE Bohnsack - Frontiers in RNA Research, 2024 - frontiersin.org
Decoration of cellular RNAs with modified RNA nucleosides is an important layer of gene
expression regulation. Throughout the transcriptome, RNA modifications influence the …
expression regulation. Throughout the transcriptome, RNA modifications influence the …
LAFITE Reveals the Complexity of Transcript Isoforms in Subcellular Fractions
Abstract Characterization of the subcellular distribution of RNA is essential for
understanding the molecular basis of biological processes. Here, the subcellular nanopore …
understanding the molecular basis of biological processes. Here, the subcellular nanopore …