Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by
metabolizing phosphatidylinositol 4, 5-bisphosphate in the plasma membrane. This process …

Mitochondria physically associate with the endoplasmic reticulum to coordinate
interorganelle calcium transfer and regulate fundamental cellular processes, including …

A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil
infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The …

Cystic fibrosis (CF) is an autosomal recessive disorder characterized by mutations in the
cystic fibrosis transmembrane conductance regulator gene, which causes multifunctional …

Defective CFTR biogenesis and activity in cystic fibrosis airways leads to airway dehydration
and impaired mucociliary clearance, resulting in chronic airway infection and inflammation …

Exosomes derived from human umbilical cord mesenchymal stem cells (UMSC‐Exos) have
shown encouraging effects in regulating inflammation and attenuating myocardial injury …

Excessive and chronic airway inflammation associated with increased morbidity and
mortality is a hallmark of cystic fibrosis (CF) airway disease. Previous studies underscored …

In this review, we have selected several outstanding studies from the American Journal of
Respiratory and Critical Care Medicine (AJRCCM), the American Journal of Respiratory Cell …

New anti-inflammatory treatments are needed for CF airway disease. Studies have
implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1α (IRE1α) …