Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

Y Xiong, A Mahmood, M Chopp - Neural Regeneration Research, 2024 - journals.lww.com
Traumatic brain injury is a serious and complex neurological condition that affects millions of
people worldwide. Despite significant advancements in the field of medicine, effective …

Therapeutic application of stem cells in the repair of traumatic brain injury

DG Adugna, H Aragie, AA Kibret… - Stem Cells and Cloning …, 2022 - Taylor & Francis
Traumatic brain injury is the main cause of injury-related deaths and disabilities throughout
the world, which is characterized by a disruption of the normal physiology of the brain …

Administration of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) to induce neural differentiation of dental pulp stem cells (DPSC) isolates

K Lott, P Collier, M Ringor, KM Howard, K Kingsley - Biomedicines, 2023 - mdpi.com
The aging populations in many countries have developed many chronic illnesses and
diseases, including chronic neurologic conditions such as Parkinson's and Azheimer's …

Regulation of extracellular vesicle-mediated immune responses against antigen-specific presentation

Y Matsuzaka, R Yashiro - Vaccines, 2022 - mdpi.com
Extracellular vesicles (EVs) produced by various immune cells, including B and T cells,
macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate …

A meta-analysis on the effectiveness of extracellular vesicles as nanosystems for targeted delivery of anticancer drugs

SA Muhammad, MS Jaafaru, S Rabiu - Molecular Pharmaceutics, 2023 - ACS Publications
While the efficacy of anticancer drugs is hampered by low bioavailability and systemic
toxicity, the uncertainty remains whether encapsulation of these drugs into natural …

Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases

P Izquierdo-Altarejos… - Neural Regeneration …, 2024 - journals.lww.com
Extracellular vesicles are released by all cell types and contain proteins, microRNAs,
mRNAs, and other bioactive molecules. Extracellular vesicles play an important role in …

Exosomes as Delivery Systems for Targeted Tumour Therapy: A Systematic Review and Meta-analysis of In vitro Studies

SA Muhammad, JS Mohammed… - Pharmaceutical …, 2023 - ingentaconnect.com
Background: Delivery systems with low immunogenicity and toxicity are believed to enhance
the efficacy of specific targeted drug delivery to cancer cells. Exosomes are potential natural …

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

KJ Habashy, S Omais, B Haupt, AM Sonabend… - Biologics, 2024 - mdpi.com
Traumatic Brain Injury (TBI) is a debilitating condition that poses a significant public health
concern. Historically linked to motor vehicle accidents, the epidemiology of TBI has evolved …

[HTML][HTML] Role of circulating exosomes in cerebrovascular diseases: a comprehensive review

Z Lu, H Tang, S Li, S Zhu, S Li… - Current …, 2023 - ncbi.nlm.nih.gov
Exosomes are lipid bilayer vesicles that contain multiple macromolecules secreted by the
parent cells and play a vital role in intercellular communication. In recent years, the function …

Efficacy of extracellular vesicles of different cell origins in traumatic brain injury: A systematic review and network meta-analysis

ZL Yang, ZY Liang, YK Lin, FB Lin, J Rao… - Frontiers in …, 2023 - frontiersin.org
Background There was still no effective treatment for traumatic brain injury (TBI). Recently,
many preclinical studies had shown promising efficacy of extracellular vesicles (EVs) from …