The innate immune system is an evolutionarily conserved system that senses and defends
against infection and irritation. Innate immune signaling is a complex cascade that quickly …

Though rare, stroke in infants and children is an important cause of mortality and chronic
morbidity in the pediatric population. Neuroimaging advances and implementation of …

Stroke is among the top 10 causes of death in children and survivors carry resulting
disabilities for decades, at substantial cost to themselves and their families. Children are not …

Background and Purpose—Focal cerebral arteriopathy accounts for up to 35% of arterial
ischemic stroke (AIS) in children and is the most important predictor of stroke recurrence …

Background Most childhood AIS is associated with nonatherosclerotic cerebral arteriopathy
1, 2—a term encompassing any pathological abnormality of the arterial circulation. This …

This review will discuss important developments in childhood arterial ischemic stroke over
the past decade, focusing on improved understanding of the causes, consequences, and …

Focal cerebral arteriopathy (FCA), a unilateral, monophasic disease of the intracranial
arteries, is one of the most common etiologies of pediatric stroke. Imaging and laboratory …

Neurological morbidity is common after pediatric stroke, with moderate to severe deficits that
can significantly impact education and social function. Care and recovery occur in phases …

Background Focal cerebral arteriopathy (FCA), a major cause of childhood arterial ischemic
stroke (AIS), can progress and lead to increased infarct size and/or recurrent stroke …

Injuries in the developing brain cause significant long-term neurological deficits. Emerging
clinical and preclinical data have demonstrated that the pathophysiology of neonatal and …