Aminoglycosides, a class of clinically important drugs, are widely used worldwide against
gram-negative bacterial infections. However, there is growing evidence that …

Hearing impairment not etiologically associated with clinical signs in other organs (non-
syndromic) is genetically heterogeneous, so that over 120 genes are currently known to be …

Aminoglycosides, cisplatin, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely
used pharmacological agents. There is a possibility, however, that the use of these agents …

Introduction Aminoglycosides are a well-known clinically relevant antibiotic family used to
treat bacterial infections in humans and animals and can produce toxic side effects …

Mitochondrial disorders are a group of metabolic conditions caused by impairment of the
oxidative phosphorylation system. There is currently no clear evidence supporting any …

In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant
(MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize …

We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP).
Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of …

Our appreciation of mitochondrial disease, in the context of both genetic and phenotypic
heterogeneity, has blossomed over recent years with successive epidemiological studies …

Background Genetic variations, including mitochondrial mutations, are important
contributors to hearing loss, especially in children, and newborn genetic screens for hearing …

Hearing loss (HL) is one of the most common causes of disability, affecting 360 million
people according to the World Health Organization (WHO). HL is most frequently of …