The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

M Amidfar, J de Oliveira, E Kucharska, J Budni, YK Kim - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer's disease and Parkinson's disease

A Nakajima, Y Ohizumi - International journal of molecular sciences, 2019 - mdpi.com
Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease

P Agostinho, RA Cunha… - Current pharmaceutical …, 2010 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the
elderly. The increase of lifeexpectancy is transforming AD into a major health-care problem …

Sex differences in neuropathology and cognitive behavior in APP/PS1/tau triple-transgenic mouse model of Alzheimer's disease

JT Yang, ZJ Wang, HY Cai, L Yuan, MM Hu, MN Wu… - Neuroscience …, 2018 - Springer
Alzheimer's disease (AD) is the most common form of dementia among the elderly,
characterized by amyloid plaques, neurofibrillary tangles, and neuroinflammation in the …

Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and tangeretin in Alzheimer's and Parkinson's disease

N Braidy, S Behzad, S Habtemariam… - CNS & neurological …, 2017 - ingentaconnect.com
Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …

Molecular mechanisms for herpes simplex virus type 1 pathogenesis in Alzheimer's disease

SA Harris, EA Harris - Frontiers in aging neuroscience, 2018 - frontiersin.org
This review focuses on research in the areas of epidemiology, neuropathology, molecular
biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative …

Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

KR Hoyt, K Obrietan - Molecular neurodegeneration, 2022 - Springer
Modulation of basic biochemical and physiological processes by the circadian timing system
is now recognized as a fundamental feature of all mammalian organ systems. Within the …

Antidepressant flavonoids and their relationship with oxidative stress

L Hritcu, R Ionita, PA Postu, GK Gupta… - Oxidative Medicine …, 2017 - Wiley Online Library
Depression is a serious disorder that affects hundreds of millions of people around the world
and causes poor quality of life, problem behaviors, and limitations in activities of daily living …

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

S Cirmi, N Ferlazzo, GE Lombardo… - Molecules, 2016 - mdpi.com
Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of
the structure and function of the central nervous system or the peripheral nervous system or …

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

A Nakajima, Y Aoyama, EJ Shin, Y Nam, HC Kim… - Behavioural brain …, 2015 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia among the elderly, is
characterized by the progressive decline of cognitive function. Increasing evidence indicates …