Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …

Despite its initial treatment as a nuisance variable, the placebo effect is now recognized as a
powerful determinant of health across many different diseases and encounters. This is in …

Modern psychedelic research remains in an early phase, and the eventual introduction of
psychedelics into clinical practice remains in doubt. In this piece, we discuss the role of …

Objective: To evaluate the use of existing practice control groups in randomized controlled
trials of behavioral interventions and the role of extrinsic health care services in the design …

Objective The PROCO RCT is a multicenter, double-blind, crossover, randomized controlled
trial (RCT) that investigated the effects of rate on analgesia in kilohertz frequency (1–10 kHz) …

Although popular discussion of testosterone's influence on males often centers on
aggression and antisocial behavior, contemporary theorists have proposed that it instead …

A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs)
have failed to show statistically significant superiority to placebo in conditions in which their …

The Cochrane risk of bias tool (RoB) is a widely used measure for methodological quality of
randomized controlled trials. This paper discusses RoB's rationale and risk of bias domains …

Background A patient's response to treatment may be influenced by the expectations that the
patient has before initiating treatment. In the context of clinical trials, the influence of …

Importance Functional abdominal pain disorders (FAPDs) can severely affect the life of
children and their families, with symptoms carrying into adulthood. Management of FADP …