Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid …
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental molecular systems biology data and …
Figure 1 iML1515 genome-scale reconstruction.(a) The iML1515 model contains 1,515 open reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 …
Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-based advice to anyone with an interest in the role of nutrition in health …
The prediction of cellular function from a genotype is a fundamental goal in biology. For metabolism, constraint-based modelling methods systematize biochemical, genetic and …
To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …
D Szklarczyk, A Franceschini, M Kuhn… - Nucleic acids …, 2010 - academic.oup.com
An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. Toward …
Over the past decade, a growing community of researchers has emerged around the use of constraint-based reconstruction and analysis (COBRA) methods to simulate, analyze and …
Reconstructed microbial metabolic networks facilitate a mechanistic description of the genotype–phenotype relationship through the deployment of constraint-based …