DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and
is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional …

Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

Full details of the development of a simple, nondestructive, and high-throughput method for
establishing DNA binding affinity and sequence selectivity are described. The method is …

The design of synthetic ligands that read the information stored in the DNA double helix has
been a long-standing goal at the interface of chemistry and biology,,,,. Cell-permeable small …

Background: Structural studies by nuclear magnetic resonance (NMR) of RNA and DNA
aptamer complexes identified through in vitro selection and amplification have provided a …

SMALL molecules that specifically bind with high affinity to any predetermined DNA
sequence in the human genome would be useful tools in molecular biology and potentially …

The cyanine dyes are among the oldest classes of synthetic compounds but continue to find
applications in a variety of fields. In many cases, the dyes act as fluorescent labels for …

Small molecules that target specific DNA sequences have the potential to control gene
expression. Ligands designed for therapeutic application must bind any predetermined DNA …