Bacteria that colonize the intestine, invade intestinal epithelial cells, and/or produce one or
more toxins are important etiologies of diarrheal disease in both industrialized and …

Abstract Guanylyl cyclase C (GC-C) was found to function as the principal receptor for heat-
stable enterotoxins (STa), major causative factors in E. co/i-induced secretory diarrhea. GC …

CD44 on lymphocytes binding to its carbohydrate ligand hyaluronan can mediate primary
adhesion (rolling interactions) of lymphocytes on vascular endothelial cells. This adhesion …

CD44 on activated T cells can initiate contact and mediate rolling on hyaluronan on
endothelial cells. We have shown that the integrin VLA-4 is used preferentially over LFA-1 in …

Hosts are protected from attack by potentially harmful enteric microorganisms, viruses, and
parasites by the polarized fully differentiated epithelial cells that make up the epithelium …

Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin,
and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of …

Members of the receptor-guanylate cyclase (rGC) family possess an intracellular catalytic
domain that is regulated by an extracellular receptor domain. GC-C, an intestinally …

Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular
domain increases the levels of intracellular cGMP. The intracellular domain of these …

Abstract Guanylyl cyclase C (GC‐C) is the receptor for the heat‐stable enterotoxin, which
causes diarrhea, and the endogenous ligands, guanylin and uroguanylin. GC‐C is …

Mutations in receptor guanylyl cyclase C (GC-C) cause severe gastrointestinal disease,
including meconium ileus, early onset acute diarrhea, and pediatric inflammatory bowel …